Natural Solutions for Pet Anxiety: How Gut Health and Mineral Balance Help Dogs and Cats Feel Calmer

Natural Solutions for Pet Anxiety

Is your dog or cat anxious, reactive, or easily stressed out?

In this post, you'll learn how improving pet gut health, correcting mineral imbalances, and using holistic tools like HTMA testing can bring calm, clarity, and comfort to your pet’s life—naturally.

Is Your Pet Showing Signs of Anxiety?

Many pets struggle with fireworks, boarding, and thunderstorm anxiety. Learn how calming minerals and gut support can help restore emotional balance naturally.

If your dog trembles during thunderstorms or your cat hides at the sound of fireworks, you’re not alone. Pet anxiety—whether in dogs or cats—is often a symptom of deeper physical imbalances like nutrient deficiencies, gut inflammation, or an overwhelmed nervous system.

While calming chews and medications may offer temporary relief, they often don’t address the root cause. That’s where a holistic, whole-body approach can make a life-changing difference.

🧠 Understanding the Biology of Pet Anxiety

When our pets show signs of anxiety—whether it’s trembling during thunderstorms, barking excessively when left alone, or hiding from guests—it’s easy to think the problem is “just behavioral.” But anxiety in pets is far more than a training issue. It’s deeply rooted in the body’s physiology, particularly the stress response system.

At the core of this system is the hypothalamic-pituitary-adrenal (HPA) axis. This triad regulates how your pet responds to stress and plays a crucial role in both acute and chronic anxiety symptoms.

Here’s how it works:

1. The hypothalamus (a brain region) first detects the threat and sends a signal to the pituitary gland.

2. The pituitary gland then signals the adrenal glands to release cortisol, the body’s main stress hormone.

3. Cortisol prepares the body to respond—but when the threat is ongoing or unresolved, cortisol levels remain elevated, leading to a cascade of health effects.

Prolonged HPA axis activation can:

• Deplete calming minerals like magnesium and calcium

• Disrupt digestion and immunity

• Sensitize the nervous system to future stressors

• Alter gut health and microbiome balance

• Increase reactivity and reduce emotional resilience

Another key player is the neurotransmitter glutamate, which acts like a gas pedal in the brain. It stimulates the HPA axis but, when left unchecked, can lead to an overactive stress response. This is where pets can become stuck in “high alert mode,” reacting to even mild stimuli with fear or hyperactivity.

At the same time, the endocannabinoid system (ECS)—an internal system designed to maintain balance—steps in to try and regulate things. The ECS helps calm the fear response, extinguish traumatic memory loops, and reduce inflammation that contributes to chronic anxiety. When supported properly (through nutrition, herbs, or supplements like hemp oil), the ECS can be a powerful ally in restoring emotional balance.

What does this mean for healing?

It tells us that true anxiety relief in pets requires a multimodal approach. We must support the gut-brain axis, stabilize the HPA response, nourish neurotransmitter pathways, and reduce systemic inflammation—all while helping our pets feel emotionally safe.

This is exactly what we guide pet parents through in the Better Gut Health Blueprint—because understanding the biology behind your pet’s anxiety is the first step to helping them heal for good.

🌿 The Role of Gut Health in Emotional Balance

Did you know that your pet’s gut produces over 90% of their serotonin? A healthy microbiome supports:

• Neurotransmitter production (GABA, serotonin)
• Immune regulation and mood stability
• Less inflammation and better digestion

When we restore gut health in dogs and cats, we often see behavior and anxiety improve dramatically. That’s why gut health is a core pillar of my Better Gut Health Blueprint.

Make sure you grab our FREE Gut Health Guide to learn more about how to optimize your pet's gut health to help better manage anxiety and stress.

📥 Download the Free Gut Health Guide Here! 

🧪 HTMA Testing: The Secret to Uncovering Mineral Deficiencies

Most anxious pets are deficient in what I call “tranquilizing minerals”: magnesium, calcium, potassium, and zinc.

These minerals are essential for a calm, balanced nervous system—but routine bloodwork often misses them. That’s why we use HTMA (Hair Tissue Mineral Analysis) in our Blueprint program. It’s non-invasive and gives a full picture of your pet’s metabolic and stress profile, and where they may be nutritionally deficient. 

HTMA reveals:

• Calming mineral deficiencies
• Adrenal burnout or overdrive
• Heavy metal toxicity (like mercury or aluminum)
• Custom supplement needs

HTMA is included in our Better Gut Health Blueprint, along with a customized supplement and food therapy plan. 

Not sure if your pet is stressed or anxious?

Many pets are great at hiding it. A simple at-home stool test can reveal if your pet's cortisol levels (stress hormones) are elevated—so you can take action early.

We recommend the In-Home Stress Test by Innovative Pet Lab. It’s non-invasive, easy to use, and helps you understand how stress may be affecting your pet’s behavior, digestion, or immune health.

🧪 Order the At-Home Pet Stress Test Here (use code NaturalPet25 for a discount)

💊 Natural Supplements for Pet Anxiety

These are my top holistic supplement recommendations to support dog AND cat anxiety naturally while building long-term emotional and gut resilience. I love Standard Process products due to their research, quality and sourcing, and they use whole foods, glandulars and herbs to support the body at a nutritional level. The pet products can also be used between dogs and cats too, making them incredibly versatile. 

🧘‍♀️ Standard Process Calming Comfort Pro

What it does: A powerful blend of l-theanine, l-tryptophan, magnesium, and calming nutrients that support serotonin and GABA production to reduce anxiety without sedation.

• Contains a blend of amino acids that interact with calming neurotransmitter pathways
• Supports neurotransmitter synthesis for behavioral health
• Beneficial for animals in stressful situations like thunderstorms, fireworks, travel, vet visits, and separation

As it is designed to be used, the ingredients in Calming Comfort Pro have no known contraindications or interactions with any drug. I've personally used this with both my cat and dog clients and have seen noticeable calming effects—plus, my cats didn't mind it being added to their food!

Dosage: See product label for dosing by weight.

🛒 Shop Standard Process Calming Comfort Pro

⚡ Standard Process Canine Adrenal Support (can be used with cats too!)

What it does: An adrenal support supplement for dogs that supports their adrenal glands’ ability to rebuild, regenerate, and respond normally to stress.

• Helps the adrenal glands respond normally to stress and metabolic demands
• Supports the glands' ability to rebuild and regenerate
• Provides vital nutritional support to related bodily organs

The adrenal glands help the body adapt to stress through the release of corticosteroids and hormones. This affects many body systems, including the pituitary and thyroid glands, autonomic nervous system, liver, duodenum, and kidneys.

Dosage: See product label for dosing by weight. Can be used daily, long-term. 

🛒 Shop Standard Process Canine Adrenal Support

🌿 VetCS CBD Oil for Pets

What it does: Supports your pet’s endocannabinoid system during acute stress like fireworks, travel, or boarding. Use short-term (up to 3 days) to help regulate fear and inflammation, but can also be used long-term for optimal health and support.

Advanced Calming Formula — a best-selling hemp oil designed for dogs with high anxiety, chronic inflammation, or nervous system imbalances. With a potent blend of CBD, CBG, CBN, and targeted terpenes, this formula supports deep relaxation and overall wellness—naturally and effectively.

500mg CBD Tincture for Cats is uniquely infused with calming catnip and silvervine to ease daily anxiety—without overstimulation. Specially crafted to support relaxation and emotional balance, this feline-friendly formula is the only one of its kind on the market.

I've personally used this brand of CBD for years with my own pets and patients. It's one of the reasons my dog with a brain tumor thrived for another year. I also love that they have cat-specific options to support relaxation without side effects.

Dosage: See product label for dosing by weight. More is not always better with CBD when treating anxiety conditions. Can be used as needed or as a daily supplement.

🛒 Shop VetCS CBD Oil (use code T101 for discount)

🍽️ Standard Process Canine & Feline Whole Body Support

What it does: Provides foundational nutritional support from whole foods, organ extracts, and botanicals—filling the gaps left by processed pet diets and supporting all body systems.

• Daily supplement for any patient
• Acts like a whole-food multivitamin to help ensure vitamin/mineral imbalances are met, especially in a stressful world

Dosage: See product label for dosing by weight. If you prefer tablets, you can use the Feline Whole Body Support. If you prefer powder, use the Canine Whole Body Support. Each can be used for either dogs or cats. Can be used daily long-term.

🛒 Shop Standard Process Whole Body Support

🌿 Standard Process Orchex

What it does: A unique blend of bovine orchic extract, adrenal and spleen tissue, and essential minerals to support the central nervous system and a calm emotional state in pets.

• Supports parasympathetic nervous system activity
• Helps regulate adrenal response in highly reactive or anxious pets
• Can be used alongside other calming supplements for a layered approach
• Especially useful for dogs with high drive, nervous tension, or excessive vocalization

Dosage:
Pets 1–20 lbs: 1 capsule twice a day with food.
Pets 21–50 lbs: 3 capsules per day with food.
Pets >50 lbs: 2 capsules twice a day with food.

⚠️ CAUTION: Not for regular daily use. Orchex is intended for acute support only. Give for 3 consecutive days with a minimum 2-week break between uses.

🛒 Shop Standard Process Orchex

🎯 Why You Should Start Now - Before Summer Stressors Hit

Summer brings more than sunshine - it brings fireworks, travel, boarding, house guests, thunderstorms, and disruptions to your pet’s routine.

By starting emotional and gut support now, your pet will:

• Build resilience before stress spikes
• Restore mineral reserves
• Reduce reactivity and flare-ups
• Feel safer, calmer, and more confident

💬 Final Thoughts: Your Pet’s Anxiety Has a Root Cause - Let’s Find It

Your pet’s anxiety isn’t bad behavior. It’s their body telling you something is out of balance—and with the right tools, we can help them heal.

Inside the online Better Gut Health Blueprint, we guide pet parents through:

• HTMA testing and interpretation, with consultations with Dr. Katie
• Custom holistic protocols for anxiety and gut health
• Weekly Q&A and personalized in-depth holistic support for 3 months with opportunities to stay in our membership for longer if needed!

Looking for more natural solutions for pet anxiety, dog gut health, or feline stress issues? Explore our full educational library at thenaturalpetdoctor.com.

*Disclaimer: This information is for educational purposes only and is not intended to replace the advice of your own veterinarian or doctor. The information contained in thenaturalpetdoctor.com is strictly for educational purposes. Therefore, if you wish to apply ideas contained in thenaturalpetdoctor.com, you are taking full responsibility for your actions. Please consult your veterinarian for medical advice for your own pets. Dr. Katie Woodley cannot answer specific questions about your pet’s medical issues or make medical recommendations for your pet without first establishing a veterinarian-client-patient relationship.  Links in the blog are typically affiliate links that let you help support us.